Reply Mechanisms of action of various ATP-sensitive potassium channel openers
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چکیده
منابع مشابه
Mechanisms of action of various ATP-sensitive potassium channel openers.
Dr. Grover’s very kind and complimentary remarks about the recent review [l] on ATP-sensitive potassium channel openers during ischemia and reperfusion are much appreciated. One point, however, causes Dr. Grover considerable concern-this is the citation of (and by implication a presumed agreement with) the comments in the paper by Richer et al. [2]. This paper was critical of the conclusions of...
متن کاملATP-sensitive potassium (K(ATP)) channel openers diazoxide and nicorandil lower intraocular pressure in vivo.
PURPOSE To evaluate the expression of ATP-sensitive potassium (K(ATP)) channel subunits and study the effect of K(ATP) channel openers diazoxide and nicorandil on intraocular pressure (IOP) in an in vivo mouse model. METHODS Expression of K(ATP) channel subunits in normal C57BL/6 mouse eyes was studied by immunohistochemistry and confocal microscopy. Wild-type C57BL/6 mice were treated with K...
متن کاملProtecting endothelial function: A novel therapeutic target of ATP-sensitive potassium channel openers.
Endothelial dysfunction is commonly observed in patients with hypertension, type II diabetes mellitus, and hypercholesteremia and is considered to be an early event in the changes accompanying atherosclerosis [1,2]. Disruption of normal endothelial function leads to loss of vasomotor control, reduced production of nitric oxide (NO), formation of a procoagulant surface, and promotion of inflamma...
متن کاملEffect of ATP-Dependent K+ Channel Openers and Blockers on Serum Concentration of Aldosterone in Rats
There are many reports for involvement of ATP-sensitive potassium channels in pancreatic, cardiac and vascular smooth muscle cells. This study examined the effect of single doses of K+ channel openers diazoxide, minoxidil and K+ channel blockers chlorpropamide, glibenclamide on serum concentration of aldosterone in male rats. Blood samples were obtained 60 minutes after drug treatment and serum...
متن کاملPreconditioning by mitochondrial ATP-sensitive potassium channel openers: An effective approach for improving the preservation of heart transplants.
BACKGROUND Recent studies have implicated mitochondrial ATP-sensitive potassium (K(ATP)) channels in the cardioprotective effects of ischemic preconditioning. The present study used a model of prolonged cold heart storage to assess whether the mitochondrial K(ATP) opener diazoxide could reproduce the protection conferred by ischemic preconditioning. METHODS AND RESULTS Fifty-four isolated rat...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 1996
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(96)90071-1